CompletedPhase 3

Sellick Interest in Rapid Sequence Induction

France3,472 participantsStarted 2014-02-04

Plain-language summary

Lung aspiration can occur when a rapid sequence induction of anesthesia is performed (emergency and/or presence of at least one risk factor for regurgitation of stomach contents). The aim of this study is to assess the Sellick maneuver, which is recommended for patient at high risk of aspiration of gastric content during induction of general anesthesia, despite the lack of solid evidence of its efficacy and possible adverse effects The primary outcome of this non inferiority study is the incidence of lung aspiration whether this maneuver is effectively applied or sham.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria : * Patients older than 18 yr undergoing general anaesthesia requiring rapid sequence induction (full stomach or presence of at least one risk factor for regurgitation of stomach content) are eligible. * Obtain informed consent from the patient or a close relative/surrogate. Should such a person be absent, the patient will be randomized according to the specifications of emergency consent and the patient will be asked to give his/her consent for the continuation of the trial when his/her condition will allow. Exclusion criteria : * Non consent patients, * Pregnancy, * Contraindication to Sellick maneuver * Contraindication to succinylcholine * Patients with predictive signs of bronchopneumonia during the preanesthetic consultation , * Patients with pulmonary contusion * Upper respiratory tract abnormalities * Laryngeal trauma * Patients requiring an alternative to direct laryngoscopy * Patients with troubles of consciousness * Use of plastic single used laryngoscopic blade * Use of rocuronium as neuromuscular blockade agent

What they're measuring

Incidence of lung aspiration

Timeframe: Within 1 hour

Trial details

NCT IDNCT02080754

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-02