CompletedNot Applicable

Effects of Physical Training on Adipose Tissue Metabolism and Insulin Sensitivity in the Menopausal Transition Phase

Denmark43 participantsStarted 2014-04

Plain-language summary

The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.

Who can participate

Age range45 Years – 57 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Premenopausal OR Postmenopausal (45-57 years) * No chronical Diseases * BMI \> 18,5 and \< 30 * Sedentary (no regular physical activity the last 2 years) * Either regular bleeding (premenopausal) OR no menstruation for at least 2 years (postmenopausal) * Plasma measurements: Premenopausal: estradiol \> 0.20nmol/l, Follicle Stimulating Hormone \< 22 IU/l and progesterone \> 2.5 nmol/l Postmenopausal: estradiol \< 0.20nmol/l, Follicle Stimulating Hormone \> 22 IU/l and progesterone from 0.3-2.5 nmol/l Exclusion Criteria: * Smoking * Excessive alcohol intake * Regular medication including hormone replacement treatment

What they're measuring

Insulin stimulated uptake of glucose in adipose tissue

Timeframe: Baseline and 3 months

Hyperinsulinemic euglycemic clamp

Timeframe: Baseline and 3 months

Adipose tissue distribution

Timeframe: Baseline and 3 months

Trial details

NCT IDNCT02076932

SponsorUniversity of Copenhagen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-01

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