UnknownNot Applicable

Dietary Treatment Study of Fat Synthesis and Risk of Cardiovascular Disease

United States48 participantsStarted 2013-07

Plain-language summary

The purpose of this study is to find out how the amount of fat or sugar in a person's diet, or the number of meals eaten each day, affect the amount of fat that people's bodies make, the types of fats in the bloodstream, and how much fat is stored in the liver. The study is funded by the National Institutes of Health.

Who can participate

Age range20 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * overweight or obese men and women * ages 20-65 years Exclusion Criteria: * pregnancy or lactation within the past six months * type 1 or 2 diabetes mellitus\] * AST and ALT above upper limit of normal (ULN) * fasting triglyceride or total cholesterol levels \>ULN * Hgb below the lower of limit of normal * positive HIV antibody test or hepatitis serologies * use of any antidiabetic medications or lipid-lowering drugs * history of surgery for obesity * change in body weight \>5% within preceding 6 months (self report) * claustrophobia, presence of metal implants * weight over 350 lbs

What they're measuring

Effect of meal composition on fractional de novo lipogenesis (fatty acid synthesis)

Timeframe: After 10-day dietary period

Trial details

NCT IDNCT02075710

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12

View on ClinicalTrials.gov More Overweight and Obesity trials