To investigate the safety, pharmacokinetics, and efficacy following 30-minute continuous intravenous administration of OPC-108459 at 0.4, 0.8, 1.6, or 2.4 mg/kg or placebo to patients with paroxysmal or persistent atrial fibrillation
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Subjects Achieving Normal Sinus Rhythm (NSR) in Patients With Paroxysmal AF
Timeframe: 90 minutes
Subjects Achieving NSR in Patients With Persistent AF
Timeframe: 90 minutes
Cmax of Plasma OPC-108459 in Patients With Paroxysmal AF
Timeframe: 0, 30, 50 minute and 2, 4, 8, 24 hour
Cmax of Plasma OPC-108459 in Patients With Persistent AF
Timeframe: 0, 30, 50 minute and 2, 4, 8, 24 hour