Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection

Inclusion Criteria: * Subjects who have one eye that meets the following criteria: * 18 years of age or older * Having a diagnosis of a corneal ulcer. * Corneal scraping sent for cultures and sensitivities. * Having been treated for at least three days with conventional broad spectrum anti infective therapy without improvement * Showing no response to the therapy by one or more of the following criteria: * Progressive thinning of cornea * Increasing diameter of corneal ulcer * Increasing diameter of corneal infiltrate * Persistent epithelial defect * Persistent inflammatory signs as iritis and hypopyon * Persistent pain Exclusion Criteria: * All subjects meeting any of the following criteria will be excluded from this study: * A corneal ulcer that has perforated * A corneal ulcer that has produced a descemetocele. * Women who may be breast-feeding and pregnant women. * Herpetic infection suggested by history or clinical evaluation.