CompletedPhase 1

The Effect of a High-dose Oral Vitamin D3 Bolus on Serum 25(OH)D3 and Vitamin D Receptor Target Gene Expression

Finland35 participantsStarted 2014-02

Plain-language summary

The purpose of the study is to investigate whether a high-dose vitamin D3 oral bolus (2000 micrograms) produces marked vitamin D receptor target gene expression response and whether there is large inter-individual variation.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Non-smoking * BMI 20-25 kg/m2. Exclusion Criteria: * History of kidney stones, renal failure or dialysis, hypercalcemia, hypo- or hyperparathyroidism, severe liver disease (cirrhosis), or sarcoidosis or other granulomatous diseases, such as active chronic tuberculosis or Wegener's granulomatosis. * Continuous use of anti-inflammatory medicines. * Regular use of supplements containing vitamin D.

What they're measuring

Change from baseline in vitamin D target gene expression

Timeframe: 24 h, 48 h, and 30 days after the baseline

Trial details

NCT IDNCT02063334

SponsorUniversity of Eastern Finland

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-06

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