CompletedPhase 1

Dermal Safety Study to Evaluate Potential Irritation of Abametapir Lotion

United States40 participantsStarted 2014-01

Plain-language summary

The purpose of the study is to determine the irritation potential of repeat applications of abametapir lotion on normal skin.

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Are healthy (to be confirmed by medical history) males or females, 18 years of age or older;
✓. In the case of females of childbearing potential, are using an acceptable form of birth control (oral/implant/injectable/transdermal contraceptives, intrauterine device, condom with spermicide, diaphragm with spermicide, abstinence, partner's vasectomy). Abstinence or vasectomized partner are acceptable if the female subject agrees to implement one of the other acceptable methods of birth control if her lifestyle/partner changes;
✓. If female of childbearing potential, have a negative urine pregnancy test (UPT) at Day 1, and are willing to submit to a pregnancy test at the end of study (EOS);
✓. Are free of any systemic or dermatologic disorder, which, in the opinion of the investigator, will interfere with the study results or increase the risk of adverse events;
✓. Are of any skin type or race, providing the skin pigmentation will allow discernment of erythema;
✓. Complete a patch study Medical Screening form as well as a Medical Personal History form; and
✓. Read, understand, and provide signed informed consent.

✕. Have any visible skin disease at the application site which, in the opinion of the investigative personnel, will interfere with the evaluation of the test site reaction;
✕. Are not willing to refrain from using topical/systemic analgesics such as aspirin (daily use of 81 mg aspirin is acceptable), Aleve, Motrin, Advil, or Nuprin for 72 hours prior to and during the study (occasional use of acetaminophen will be permitted);
✕. Are using inhaled/systemic/topical corticosteroids in the 3 weeks prior to and during the study, or systemic/topical antihistamines for 72 hours prior to and during the study;
✕. Are using medication which, in the opinion of the investigative personnel, will interfere with the study results, including anti-inflammatory medications;
✕. Are unwilling or unable to refrain from the use of sunscreens, cosmetics, creams, ointments, lotions, or similar products on the back during the study;
✕. Have psoriasis and/or active atopic dermatitis/eczema;
✕. Are females who are pregnant, plan to become pregnant during the study, or are breast-feeding a child;
✕. Have a known sensitivity to constituents present in the material being evaluated;

Potential of Abametapir Lotion to Cause Irritation After Repeated Topical Application to the Healthy Skin of Humans.

Timeframe: 21 days

NCT IDNCT02061813

SponsorDr. Reddy's Laboratories Limited

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2014-01

Results submitted2021-05-15

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Are healthy (to be confirmed by medical history) males or females, 18 years of age or older;
✓. In the case of females of childbearing potential, are using an acceptable form of birth control (oral/implant/injectable/transdermal contraceptives, intrauterine device, condom with spermicide, diaphragm with spermicide, abstinence, partner's vasectomy). Abstinence or vasectomized partner are acceptable if the female subject agrees to implement one of the other acceptable methods of birth control if her lifestyle/partner changes;
✓. If female of childbearing potential, have a negative urine pregnancy test (UPT) at Day 1, and are willing to submit to a pregnancy test at the end of study (EOS);
✓. Are free of any systemic or dermatologic disorder, which, in the opinion of the investigator, will interfere with the study results or increase the risk of adverse events;
✓. Are of any skin type or race, providing the skin pigmentation will allow discernment of erythema;
✓. Complete a patch study Medical Screening form as well as a Medical Personal History form; and
✓. Read, understand, and provide signed informed consent.

✕. Have any visible skin disease at the application site which, in the opinion of the investigative personnel, will interfere with the evaluation of the test site reaction;
✕. Are not willing to refrain from using topical/systemic analgesics such as aspirin (daily use of 81 mg aspirin is acceptable), Aleve, Motrin, Advil, or Nuprin for 72 hours prior to and during the study (occasional use of acetaminophen will be permitted);
✕. Are using inhaled/systemic/topical corticosteroids in the 3 weeks prior to and during the study, or systemic/topical antihistamines for 72 hours prior to and during the study;
✕. Are using medication which, in the opinion of the investigative personnel, will interfere with the study results, including anti-inflammatory medications;
✕. Are unwilling or unable to refrain from the use of sunscreens, cosmetics, creams, ointments, lotions, or similar products on the back during the study;
✕. Have psoriasis and/or active atopic dermatitis/eczema;
✕. Are females who are pregnant, plan to become pregnant during the study, or are breast-feeding a child;
✕. Have a known sensitivity to constituents present in the material being evaluated;