TerminatedNot Applicable

REFRESH: Receptivity Enhancement by Follicular-phase Renewal After Endometrial ScratcHing

Stopped: Safety concerns, apparent futility and protracted recruitment

Belgium200 participantsStarted 2014-03

Plain-language summary

A randomised controlled open-label clinical trial to assess the effect of artificially induced endometrial injury and repair during ovarian stimulation on the clinical pregnancy rate of an antagonist downregulated in-vitro fertilisation cycle

Who can participate

Age range18 Years – 40 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Fresh IVF/ICSI cycle * Antagonist down-regulation * Signed informed consent Exclusion Criteria: * Other known reasons for impaired implantation (i.e. hydrosalpinx, fibroid distorting the endometrial cavity, Asherman's syndrome, thrombophilia or endometrial tuberculosis) * Oocyte donation acceptors * Frozen egg transfers * Embryos planned to undergo preimplantation genetic diagnosis (PGD) * BMI \>35 or \<18 * Women already recruited for another trial on medically assisted procreation during the same cycle * Women who have previously enrolled in the trial * Those unable to comprehend the investigational nature of the proposed study

What they're measuring

Clinical pregnancy rate

Timeframe: 12 weeks

Trial details

NCT IDNCT02061228

SponsorUniversitair Ziekenhuis Brussel

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-02-26

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