CompletedPhase 4

Impact of Oral Antibiotic Treatment on C. Difficile

United States33 participantsStarted 2014-06-10

Plain-language summary

The overall aim is to characterize and to compare the extent and quantity of C. difficile stool shedding, perianal colonization and environmental contamination in patients who received oral fidaxomicin, oral metronidazole, or oral vancomycin. This is a prospective, randomized, microbiologic and molecular, study of environmental contamination from patients with proven C. difficile associated diarrhea (CDAD).

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * adult patients with microbiology-proven CDAD * provides informed consent * eligible to receive oral antibiotic therapy Exclusion Criteria: * prisoners * pregnant women * children \<18 years * patients who have contra-indications for perianal swabs, those who has medical conditions that would invalidate the results of the swabs * patients requiring intravenous therapy for treatment of CDAD * patients who do not consent and those who withdraw consent

What they're measuring

Change in Total Median Total Colony Forming Units (CFU) of C. Difficile Identified in the Hospital Room Environment for Each Antibiotic Treatment Group.

Timeframe: Days 0, 3, 7 and 14.

Trial details

NCT IDNCT02057198

SponsorDuke University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-06-27

Results submitted2019-07-23

View on ClinicalTrials.gov More C. Difficile trials