CompletedNot Applicable

Computational Tools for Early Diagnosis of Memory Disorders

Finland126 participantsStarted 2013-12

Plain-language summary

The Virtual Physiological Human: DementiA Research Enabled by IT (VPH-DARE@IT) is a four-year IT-project funded through the European Union (EU). The project consortium involves a total of 21 universities and industrial partners from 10 European countries. The project delivers the first patient-specific predictive models for early differential diagnosis of dementia and their evolution. An integrated clinical decision support platform will be validated / tested by access to a dozen databases of international cross-sectional and longitudinal studies. As a part of the VPH-DARE@IT project, a new prospective cohort will be collected in Kuopio. This prospective cohort will be used to test further the modeling approaches and tools developed by using the retrospective databases.

Who can participate

Age range50 Years – 85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Inclusion criteria for subjects with dementia (AD, VAD, FTD) - The inclusion criteria will be based on international research criteria: * Diagnosis of probable AD according to National Institute of Neurological and Communicative Disorders and Stroke Alzheimer's (NINCDS-ADRDA) criteria (McKhann et al.1984) and diagnosis of prodromal AD according to Dubois et al., 2007 criteria * Diagnosis of FTD according to the clinical diagnostic criteria of Neary et al., 1998 * Diagnosis of VAD according to diagnostic criteria for research studies by the NINDSAIREN International Workshop (Román et al., 1993) Inclusion criteria for subjects with MCI * Referral because of cognitive impairments * Diagnosis criteria for amnestic and nonamnestic MCI (Petersen, 2004, Petersen and Morris, 2005) Inclusion criteria for control subjects * Mini-mental state examination (MMSE) score above or equal to 27 * Overall score on the Clinical Dementia Rating (CDR) scale of 0 Exclusion Criteria: Exclusion criteria for all subjects * Other causes of dementia * Obvious brain, systemic or psychiatric disorders that could potentially affect cognitive functions such as stroke, severe depression, or endocrine disorders Exclusion criteria for control subjects and subjects with MCI \- Diagnosis of dementia according to DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) criteria at baseline

What they're measuring

Sensitivity, specificity and accuracy of models for diagnosis of memory disorders

Timeframe: during a single visit, i.e., day 1 and for one study group (MCI) after 18 month follow-up

Trial details

NCT IDNCT02050464

SponsorUniversity of Eastern Finland

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2017-04