This study will determine whether Ataciguat (HMR1766) is well-tolerated in patients with mild to moderate calcific aortic valve stenosis. The primary focus of these studies will be on changes in blood pressure and orthostatic tolerance (i.e., ability to stand up without passing out), and determining whether treatment with Ataciguat results in significant reductions in blood pressure in this patient population.
Age range
50 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of patients experiencing orthostatic hypotension
Timeframe: Baseline - 14 days
The change in blood pressure following the transition from sitting to standing
Timeframe: Baseline - 14 days
The change in blood pressure following progressive head-up tilt
Timeframe: Baseline - 14 days
Subject self-reports of light-headedness/orthostatic intolerance during the standing test and the head-up tilt testing
Timeframe: Baseline - 14 days