CompletedNot Applicable

Tear Analysis by Isoelectric Focusing in Clinically Isolated Syndrome as Multiple Sclerosis Criterion

France165 participantsStarted 2012-10

Plain-language summary

This is a multicentric and prospective study for the validation of a diagnostic method in multiple sclerosis. Our hypothesis is that there is a characteristic profile of tears that can be recognized in order to help in the diagnosis of this pathology and that could possibly replace the lumbar punction which is an invasive method. Semi-automatic and automatic techniques of isoelectric focusing will be developed for analyzing data from tears. These results will help in the identification of markers of this disease.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18 years old or more * Clinically isolated syndrome of less than 3 months of onset * Informed consent to participate Exclusion Criteria: * Progressive primary multiple sclerosis * Relapsing remitting multiple sclerosis * Persons wearing contact lenses * Ocular Infection * Corticoid treatment at least 30 days before sampling * Immunosuppressive or immunomodulatory treatment at least 3 months before sampling * Pregnancy or breast feeding * No coverage by the Social Insurance

What they're measuring

Test of the concordance coefficient between the analysis of tears and the analysis of cerebrospinal fluid

Timeframe: two years after

Trial details

NCT IDNCT02043964

SponsorLille Catholic University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-06

View on ClinicalTrials.gov More Clinically Isolated Syndrome trials