CompletedNot Applicable

Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients

China180 participantsStarted 2014-02

Plain-language summary

Purpose: To explore and compare antihyperalgesic effects of butorphanol, flurbiprofen axetil, and a combination of both received before anesthesia induction. To evaluate and examine the incidence of adverse effects with the purpose of selecting the optimum dose. .

Who can participate

Age range20 Years – 60 Years

SexALL

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Inclusion criteria

✓. Subject is scheduled to undergo lower abdominal surgery under a short general anesthesia of less than 2 hours
✓. Subject's American Society of Anesthesiologists physical status is I-II.
✓. The subject's parent/legally authorized guardian has given written informed consent to participate.

Exclusion criteria

✕. Subject has a diagnosis of renal or liver failure.
✕. Subject has a diagnosis of Insulin dependent diabetes.
✕. Subject is allergy and contraindication to butorphanol or NSAIDs.
✕. Subject has a history of chronic pain, a history of alcohol or opioid abuse, pre-existing therapy with opioids, intake of any analgesic drug within 48 hours before surgery.
✕. Subject has any contraindication for the use of patient-controlled analgesia (PCA).
✕. Subject is pregnant or breast-feeding.
✕. Subject is obese (body mass index \>30kg/m\^2).

What they're measuring

Mechanical Hyperalgesia Threshold on the Dominant Inner Forearm

Timeframe: 24 hours after surgery

Trial details

NCT IDNCT02043366

SponsorTianjin Medical University General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-06

Results submitted2015-08-27

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