Muscle Training Induced Angiogenesis in COPD (NCT02040363) | Clinical Trial Compass
CompletedNot Applicable
Muscle Training Induced Angiogenesis in COPD
France22 participantsStarted 2014-01
Plain-language summary
COPD patients experiment a peripheral muscle dysfunction which impact their exercise tolerance and health-related quality of life. The capillary to fiber interface is reduced and impact the exercise capacity of the patients. While the muscle capillary creation in response to exercise training is blunted in COPD patients, the maturation of the neo-capillaries could also be blunted and contribute to the impaired aniogionenesis in patients. Because the capillary maturation is a sensitive and dynamic process, only different modalities of exercise training and multiple time-points of measures would allow to capture this microvascular adaptation.
Aim of the study : Compare the muscle capillary maturation in response to training at 5 and 10 weeks, in sedentary healthy subject trained at the intensity of the ventilatory threshold (60-65% of VO2max), versus :- COPD patients trained at a similar intensity (60-65% of VO2max)- COPD patients trained at a similar absolute intensity (90% of VO2max).
Who can participate
Age range
40 Years – 78 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* COPD patients :
* FEV1\<80%pred.
* non exacerbation during the past 4 weeks
* no oxygen therapy, -
Healthy subjects:
* \<150min/week of moderate-to-vigorous physical activity,
* Voorrips score \<9
Exclusion Criteria:
* Unstable comorbidity
* Long term oxygen therapy or ventilation
* Rehabilitation program during the past 12 months
* nutritional supplementation during the past 4 weeks
* allopurinol or N-acetylcystein during the past 4 weeks
* long corticosteroid treatment during the past 6 months
* hyperreactivity to xylocain
* anticoagulant or platelet aggregation inhibitors treatment
* participation to an other research study-pregnancy or impossibility to provide informed consent, ...
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial looked at blood vessel growth in the thigh muscles of people with COPD by taking muscle biopsies — how does that kind of muscle-level testing compare to what you're already doing to assess my muscle function, and would those findings change my treatment plan?
2Since this trial is completed, have the results been published, and if so, what did they actually show about whether exercise training improved blood supply to the leg muscles in people with COPD like me?
3The trial focused on peripheral muscle dysfunction as a separate problem from the lungs themselves — do you think my leg muscle weakness is contributing significantly to my symptoms, and should that change how we think about my rehab or exercise program?
4This study used a specific type of exercise training to try to stimulate muscle angiogenesis — is that kind of targeted muscle training something available to me now through pulmonary rehab, or is it still mainly a research approach?
5Because this trial is listed as Phase NA, meaning it was more of a mechanistic or observational study than a treatment trial, does that mean the findings are about understanding the biology rather than proving a new therapy works, and how does that affect what I should realistically expect from exercise as part of my COPD care?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Capillary-o-fiber ratio assessed by immunochemistry on a muscle biopsy of the vastus lateralis of the quadriceps
Timeframe: 5 weeks
2
Capillary-o-fiber ratio assessed by immunochemistry on a muscle biopsy of the vastus lateralis of the quadriceps