Immunogenicity and Safety of 4 Prime-boost Combinations of HIV Vaccine Candidates in Healthy Volunteers

Inclusion Criteria: * Written and signed informed consent * Subject at low risk to contract HIV i.e. * no history of injecting drug use in the previous ten years; * no gonorrhea or syphilis in the last six months; * no high risk partner (e.g. injecting drug user, HIV positive partner) either currently or within the past six months ; * no unprotected anal intercourse in the last six months, outside a relationship with a regular partner known/presumed to be HIV negative ; * no unprotected vaginal intercourse in the last six months outside a relationship with a regular known/presumed HIV negative partner * Available for follow-up for the duration of the study (56 weeks from screening) * Willing to undergo a HIV test * Willing to undergo a genital infection screen * If heterosexually active female, using an effective method of contraception with partner (combined oral contraceptive pill; injectable contraceptive; contraceptive implant/patch; IntraUterine Contraceptive Device (IUCD); consistent record with condoms if using these; physiological or anatomical sterility in self or partner) from 14 days prior to the first vaccination until 4 months after the last, and willing to undergo urine pregnancy tests prior to each vaccination * If heterosexually active male, using an effective method of contraception with their partner from the first day of vaccination until 4 months after the last vaccination * Subject registered in French Health ministry computerised file and aut…