Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis

Inclusion Criteria: * Skin biopsy in early disease showing apoptotic keratinocytes in the epidermis and in more advanced disease necrosis of the entire epidermis * Epidermal detachment or erythematous to purpuric macules involving more than 10% of body surface area in addition to involvement of the oropharynx; there may be further involvement of other mucosal surfaces, ie. conjunctivae, gastrointestinal tract, respiratory and genitourinary epithelia * Age of 18 years old or older * The patient is expected to survive longer than 48 hours Exclusion Criteria: * Skin detachment above 90% of the body surface area * Skin detachment has not progressed during the previous 48 hours * A positive serum pregnancy test * Age \< 18 years old * Known hematologic or solid organ malignancy