Prevention of Dialysis Catheter Malfunction With Prophylactic Use of a Taurolidine Containing Urokinase

Inclusion Criteria: * Adult, prevalent hemodialysis patients * Informed and consented * Hemodialysis 3x/week via a tunneled cuffed catheter * Urokinase administration at least two times during the previous 6 months (with more than a week between 2 administrations) * Adequate catheter function during the week before inclusion (defined by blood flow more than 250ml/min on each dialysis session and blood flow within 15% of the maximal blood flow after the last Urokinase administration) Exclusion Criteria: * Presence of heparin-induced thrombocytopenia * Major hemorrhage or intracranial bleeding in the previous 3 months * Pericarditis * Intolerance to Taurolidine, citrate or to Urokinase * Active catheter-related infection * Catheter in the femoral vein