Chromatic Multifocal Pupillometer for Detection and Follow-up of Acute Head Injury

Inclusion Criteria: * Healthy subjects - * Male or female patients, age between 18 and 70 years, inclusive * Informed written consent will be obtained from all participants. * Normal eye examination * Best-corrected visual acuity (BCVA) of 20/20 * Normal color vision test (Roth-28-hue test) * Written informed consent to participate in the study, * TBI-patients: * Male or female patients, age between 18 and 70 years, inclusive * Initiation of study before the insertion of the ICP monitor. * TBI diagnosed by history and clinical examination * Glasgow Coma Scale (GCS) score between 3 and 8, inclusive * Evidence of TBI confirmed by abnormalities consistent with trauma on CT scan upon admission (diffuse injury II-IV, evacuated and non-evacuated mass lesion, Marshall's CT Classification) * Indication for ICP monitoring * Written informed consent to participate in the study, signed by a family member and independent physician. Exclusion Criteria: * Healthy subjects * History of past or present ocular disease * Use of any topical or systemic medications that could adversely influence efferent pupil movements * TBI-patients * High levels of barbiturate medications as they abolish pupillary responsiveness * Coma suspected to be primarily due to other causes (e.g. alcohol) * Preexisting clinically significant disease or chronic condition that can be ascertained at the time of admission and could affect pupillary response or measurement (such as known retinal dystrophy disease, glauco…