UnknownPhase 4

Intensive Statin Therapy Effect on Post-Operative Atrial Fibrillation (POAF)

United States200 participantsStarted 2013-08

Plain-language summary

This study will compare the effects of 20 mg of atorvastatin to 80 mg of atorvastatin for the prevention of atrial fibrillation after cardiothoracic surgery. The study hypothesis is that 80 mg of atorvastatin will be more effective at preventing atrial fibrillation compared to 20 mg.

Who can participate

Age range19 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 19 or older * Undergoing elective cardiothoracic surgery Exclusion Criteria: * Emergency cardiothoracic surgery * History of permanent atrial fibrillation * Acute coronary syndrome within 7 days * Antiarrhythmic drug use in the past 3 months * Receiving maximal tolerated dose of statin therapy * Receiving fibrate therapy * History of statin intolerance * Significant liver impairment (aspartate aminotransferase/alanine aminotransferase(AST/ALT)\>2x ULN) * Serum Creatinine \> 3 mg/dl * Pregnancy or breastfeeding

What they're measuring

Occurrence of atrial fibrillation by hospital discharge

Timeframe: Hospital discharge, an expected 5-7 days

Trial details

NCT IDNCT02029534

SponsorCreighton University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-06

Contact for this trial

Caroline Nubel

402-280-4032 carolinenubel@creighton.edu

View on ClinicalTrials.gov More Cardiothoracic Surgery trials