Everolimus With and Without Temozolomide in Adult Low Grade Glioma

Inclusion Criteria: * Age \>= 18 years * Karnofsky performance scale score (KPS) \>= 60 * Adequate bone marrow function as shown by: Absolute Neutrophil Count (ANC) \>= 1.5 x 10\^9/L, Platelets \>= 100 x 10\^9/L, hemoglobin \>= 9.0 g/dL; * Adequate liver function as shown by: Total serum bilirubin ≤ 2.0 mg/dL, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \<=2.5x upper limit of normal (ULN), International Normalized Ratio (INR) \<= 2; * Adequate renal function: serum creatinine \<=1.5 x ULN; * Fasting serum cholesterol \<= 300 mg/dL OR \<= 7.75 mmol/L AND fasting triglycerides \<= 2.5x ULN. NOTE: In case one or both of these thresholds are exceeded, the patient can only be included after initiation of appropriate lipid lowering medication with confirmed reduction of lab values to within eligibility parameters; * Signed informed consent prior to any screening procedures * Histologically proven supratentorial low-grade glioma at initial diagnosis; pathology must have been reviewed by University of California, San Francisco (UCSF) neuropathology. Eligible low-grade gliomas include: astrocytoma, oligodendroglioma and mixed oligoastrocytoma. Pilocytic astrocytomas are excluded. * Patient's tumor must have documentation of the presence of an Isocitrate dehydrogenase 1 (IDH1) and/or Isocitrate dehydrogenase 2 (IDH2) mutation of any type. * Results of 1p/19q chromosomal status and p-PRAS40 testing must be available to permit treatment selection. * Evaluable dis…