CompletedPhase 2

Evaluation of Predictors of Aortic Aneurysm Growth and Rupture

United States66 participantsStarted 2012-05

Plain-language summary

The goal is to non-invasively study the metabolic processes within the aortic wall that are thought to explain progression to clinical manifestations of an aortic aneurysm. Hypothesis is that the non-invasive imaging of Abdominal Aortic Aneurysm (AAA) with contrast ultrasound, coupled with serum biomarker measurements will allow the identification of the vulnerable aortic wall and patients who are at risk of AAA growth or rupture.

Who can participate

Age range

21 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of AAA with confirmation of diagnosis of any size aneurysm with imaging. * 21 years of age or older * ability to give informed consent. Exclusion Criteria: * Inability to provide an informed consent * Known allergy to Definity * Unstable cardiopulmonary conditions * pregnancy

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Annual Aneurysm Growth Rate Between Patients With and Without Micro Bubble Uptake

Timeframe: Up to 5 years or time of aneurysm repair surgery.

Number of Participants With Microbubble Uptake

Timeframe: At the first follow-up evaluation at 6 months

Trial details

NCT IDNCT02022436

SponsorRabih A. Chaer

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-02

Results submitted2023-05-15

View on ClinicalTrials.gov More Abdominal Aortic Aneurysm trials