Evidence Based Diagnostics and Treatment Planning Solution for Traumatic Brain Injuries

Inclusion Criteria: * Severe or moderate brain trauma subjects with need of ICU care: * Glasgow Coma Score (GCS) ≤ 8 after the primary stabilization has been performed in the field (= patient not hypoxic or hypotensive) and at least 30 min interval from the moment of injury. * GCS 9 - 13 and the patient is deteriorating * The patient has GCS ≤ 13 and has other injuries, which require interventions for hemodynamic or ventilatory incidents * The patient is in urgent need of neurosurgery (craniotomy, impression skull fracture, severe haemorrhagic contusion, or ICP measurement) Moderate or mild brain trauma not in need of ICU care: \- All other patients who fulfil the diagnostic criteria for an acute TBI but without any exclusion criteria defined below Exclusion Criteria: * Age \< 18 years at study entry * Blast-induced TBI * Perforating or penetrating mechanism of TBI * Unable to live independently because of a brain disease (= e.g. people with moderate dementia, Down's syndrome, cerebral palsy etc.) or other medical cause before the injury * TBIs or suspected TBIs not needing cranial CT imaging (excludes the mildest TBIs with negligible risk for incomplete recovery) Inclusion criteria for control subjects * Age ≥ 18 years at study entry * Acute orthopaedic non-trivial trauma that needs either surgery or conservative measures and clinical follow-up (including mere superficial soft tissue injuries) Exclusion criteria for control subjects * Age \< 18 years at study entry …