Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB - (NCT02021448) | Clinical Trial Compass
TerminatedNot Applicable
Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB -
Stopped: difficulty in recruiting
France188 participantsStarted 2013-12
Plain-language summary
Investigate whether the course of an isolated nocturnal alveolar hypoventilation can predict the future occurrence of obesity-hypoventilation syndrome (OHS) in obese subjects
Who can participate
Age range18 Years – 65 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria:
* Obese volunteer Subject (BMI\> 30 kg/m2)
* Adults of either sex
* Social security affiliation
* Written informed consent
Exclusion criteria:
* Confirmed OHS at baseline defined by a daytime hypercapnia with PaCO2\> 45mmHg
* Any cause of chronic respiratory failure other than obesity such as COPD, chest deformation, phrenic nerve paralysis, pulmonary fibrosis, neuromuscular disease, a history of mutilating thoracic surgery ...
* Obstructive ventilatory defect with FEV1/ FVC \<70% post-bronchodilator
* Long term oxygen therapy, noninvasive ventilation, continuous positive airway pressure
* Any serious illness involving life-threatening within 3 years after inclusion
* Drug or alcohol abuse
* Pregnancy