CompletedNot Applicable

Vascular Inflammation Imaging Using Somatostatin Receptor Positron Emission Tomography

United Kingdom42 participantsStarted 2014-08

Plain-language summary

This VISION study aims to investigate the role of inflammation in atherosclerosis using 68Ga- DOTATATE PET, and to validate 68Ga-DOTATATE PET imaging for the detection and quantification of vascular inflammation in the aorta, coronary and carotid arteries. This study will test the hypothesis that in subjects undergoing carotid endarterectomy for symptomatic plaques, there will be a positive correlation between carotid artery 68Ga-DOTATATE PET signal and the underlying degree of carotid inflammation measured by immunohistochemical analysis.

Who can participate

Age range40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥40 years of age * Can provide written, fully informed consent * Have had a transient ischemic attack (TIA) or stroke within the preceding four weeks due to carotid artery atherosclerosis; or have ≥30% carotid artery or epicardial coronary artery stenosis Exclusion Criteria: * Renal impairment (eGFR\<30mls/min) * History of contrast nephropathy * Atrial fibrillation * Any condition, in the opinion of the investigator, which prevents the participant from lying flat during scanning * Women of childbearing potential * Inability to provide written informed consent * Haemorrhagic stroke within 3 months of study entry * Total occlusion of a culprit carotid artery * Any medical condition, vital sign or laboratory value that, in the opinion of the investigator, makes the subject ineligible for inclusion

What they're measuring

Correlation of 68Ga-DOTATATE PET signal to carotid plaque inflammation

Timeframe: Baseline

Trial details

NCT IDNCT02021188

SponsorUniversity of Cambridge

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2016-08