This primary aim of this study is to test the impact of a strategy of perioperative chloride-restriction through intravenous (IV) fluid therapy on the incidence of acute kidney injury after cardiac surgery. A prospective, open-label, single-centre 4-period sequential study of varying strategies of perioperative IV fluid composition will test the hypothesis that a perioperative protocol for the administration of chloride-poor intravenous fluids compared to chloride-rich intravenous fluids will reduce the incidence of AKI after adult cardiothoracic surgery.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Peak ∆ serum creatinine
Timeframe: 5 days postoperatively
AKI ≥stage2
Timeframe: 5 days postoperatively