The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease

* INCLUSION CRITERIA: A diagnosis of interstitial lung disease, including idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonitis (NSIP), sarcoidosis, or other form of chronic lung fibrosis based on clinical context via clinic note from a pulmonologist. Individuals with ILD referred for pulmonary rehabilitation who are 21-80 years of age and live in the Washington metropolitan area. No episodes of fainting or significant chest pain for at least one month. No prior pulmonary rehabilitation received within the last 6 months and not currently in a maintenance program. Physically inactive (no participation in a structured exercise program as defined as more than 30 minutes of exercise 3 or more days a week within the last 6 months). EXCLUSION CRITERIA: Other medical conditions that would impair aerobic capacity or the ability to engage in physical activity, including other pulmonary, cardiovascular, neurological, musculoskeletal or metabolic conditions Other medical conditions that may pose a risk to exercise testing or training as determined by the investigators (for example, peripheral vascular disease) Diagnosis of pulmonary hypertension Inability to maintain a resting oxygen saturation greater than or equal to 90% SpO2, measured by pulse oximetry on supplemental oxygen Inability to complete a treadmill cardiopulmonary exercise test. Significant hepatic or renal dysfunction. Metastatic cancer with a life expectancy of less than one year. Active…