CompletedNot Applicable

Decompressive Cervical Surgery and Hypertension

China50 participantsStarted 2014-06

Plain-language summary

There is a relationship between CSM and hypertension, probably a cause/effect relationship, and investigators term this type of hypertension "cervicogenic hypertension". Abnormally functioning serotonergic pacemaker cells in the dorsal raphe nucleus inappropriately activate and inhibit parts of the central and autonomic nervous systems as part of a chronic stress response, which causes hypertension and migraine. This theory is now being expanded to encompass both CSM and essential hypertension, the idea being that these two conditions are intimately related.

Who can participate

Age range18 Years – 84 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Established diagnosis of cervical spondylosis myelopathy * Be at least 18 years of age * Office-measured systolic BP≧140mmHg * Ability to adhere to study protocol * Have signed an approved informed consent form for participation in this study Exclusion Criteria: * Have hypertension secondary to a treatable cause * Have prior cervical spine surgery * Are pregnant or contemplating pregnancy during the 3-month follow-up period * People deny to join the study * Are unable to comply with protocol requirements * Are unlikely to survive the protocol follow-up period * Are enrolled in another concurrent clinical trial * Visual Analogue Scale≥4

What they're measuring

Change from baseline in the systolic blood pressure(SBP) measured by 24-hour Ambulatory Blood Pressure Monitoring(ABPM) on 1st month and 3th month post-operation.

Timeframe: twice ABPM prior to operation and 1st month, 3th month post-operation.

Trial details

NCT IDNCT02016768

SponsorPeking University First Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2016-12