EXCELLA Post-Approval Study

Inclusion Criteria: * The patient must be ≥18 years of age. * The patient must have angina pectoris as defined by the Canadian Cardiovascular Society Classification, documented silent ischemia, or a positive functional study. * The patient has a planned intervention of up to two lesions each coverable by a single stent located in separate major epicardial territories. Each lesion/vessel must meet the following criteria: * De novo lesion * The target lesion reference site must be visually estimated to be ≥ 2.5 mm and ≤ 4.0 mm in diameter. * The target vessel must be a major coronary artery or major branch with a visually estimated stenosis of ≥ 50% and \<100%. * The visually estimated target lesion length must be ≤ 34 mm (DESyne Novolimus Eluting CSS) (Arm A)\*. * The visually estimated target lesion length must be ≤ 34 mm (DESyne BD Novolimus Eluting CSS) (Arm B)\* * ≥ TIMI 1 coronary flow. \*Subject to commercial availability of product sizes in the specific region/country. * The patient must be an acceptable candidate for coronary artery bypass surgery. * Female subjects of childbearing potential must have a negative pregnancy test within seven (7) days before the procedure and must agree to use a reliable method of contraception from the time of screening through 12 months after the index procedure. * The patient and the patient's physician agree to the follow-up schedule. * The patient or guardian who has been informed of the nature of the study agrees to its provisio…