TerminatedPhase 4

Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD

Stopped: Slow enrollment

Canada18 participantsStarted 2014-06

Plain-language summary

An emerging cause of heart attack in young women is a dissection (or tear) in the coronary arteries. Many of these young women continue to have chest pain long after the tear has healed and this is thought to be due to problems with their small blood vessels of the heart (or microcirculation). We want to determine whether commonly used medications for coronary artery disease including statins (for cholesterol) and angiotensin-converting enzyme inhibitors (for blood pressure) reduce chest pain and improve small vessel function in these patients.

Who can participate

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Any woman with prior SCAD who is at least 3 months out from her SCAD and has ongoing symptoms of chest pain. * Females of child-bearing age must have a negative pregnancy test at enrollment * Coronary Flow Reserve(CFR) \< 3.0 Exclusion Criteria: * Renal dysfunction with Glomerular Filtration Rate \<50 ml/min * Patients not willing to undergo coronary angiography * Patients with a prior intolerance or allergy to rosuvastatin or ramipril * Inability to perform CRT or CFR \>3.0 * Obstructive coronary artery disease (stenosis \>50% in any artery) or residual dissection \>50% with distal flow abnormalities

What they're measuring

Angina frequency domain of the SAQ

Timeframe: 16 weeks after each intervention

Trial details

NCT IDNCT02008786

SponsorCardiology Research UBC

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-09-13

View on ClinicalTrials.gov More Coronary Artery Dissection, Spontaneous trials