TerminatedPhase 4

Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD

Stopped: Slow enrollment

Canada18 participantsStarted 2014-06

Plain-language summary

An emerging cause of heart attack in young women is a dissection (or tear) in the coronary arteries. Many of these young women continue to have chest pain long after the tear has healed and this is thought to be due to problems with their small blood vessels of the heart (or microcirculation). We want to determine whether commonly used medications for coronary artery disease including statins (for cholesterol) and angiotensin-converting enzyme inhibitors (for blood pressure) reduce chest pain and improve small vessel function in these patients.

Who can participate

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Any woman with prior SCAD who is at least 3 months out from her SCAD and has ongoing symptoms of chest pain. * Females of child-bearing age must have a negative pregnancy test at enrollment * Coronary Flow Reserve(CFR) \< 3.0 Exclusion Criteria: * Renal dysfunction with Glomerular Filtration Rate \<50 ml/min * Patients not willing to undergo coronary angiography * Patients with a prior intolerance or allergy to rosuvastatin or ramipril * Inability to perform CRT or CFR \>3.0 * Obstructive coronary artery disease (stenosis \>50% in any artery) or residual dissection \>50% with distal flow abnormalities

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Angina frequency domain of the SAQ

Timeframe: 16 weeks after each intervention

Trial details

NCT IDNCT02008786

SponsorCardiology Research UBC

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-09-13

View on ClinicalTrials.gov More Coronary Artery Dissection, Spontaneous trials

Plain-language summary

Who can participate

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.