The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease

Inclusion Criteria: * Age ≥ 20 years * MAC/MAB lung disease: Diagnosis is based on the guidelines made by American Thoracic Society (Table 1)\[1\]. In brief, there should be pulmonary symptoms, comparable findings in chest image and appropriate exclusion other possible causes as well as meeting the microbiology criteria. * MAC/MAB pulmonary colonizers: Those without fulfilling the diagnostic criteria but having at least one set of positive sputum for MAC/MAB are defined. * Healthy controls: patient without documented MAC/MAB lung disease and pulmonary colonization Exclusion Criteria: * Patients who have acquired immunodeficiency syndrome * Patients who have bleeding tendency which cannot tolerate venous puncture such as hemophilia, thrombocytopenia. * refusal of recruitment