Genetic Variants Associated With Adolescent Suicide Attempts
France250 participantsStarted 2013-12
Plain-language summary
Suicidal behaviors is known to aggregate in families. The purpose of this study is to evaluate association between common polymorphisms in genes important for neurobiological pathways linked to suicidal behaviors and suicide attempt among adolescents patient.
Who can participate
Age range13 Years – 17 Years
SexALL
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Inclusion Criteria:
Case :
* Age at admission between 13 and 17 years old
* Hospitalized for attempted suicide
* Absence of prominent mental retardation or organic brain damage
* Fluent in French
* Able to comprehend the study procedures and to undergo entry assessments safely
* Provided written informed consent for study participation, and additional consent from the patient's parents or guardians
* Northern and Western European ancestry (HapMap-CEU)
* Medical insurance coverage
Control :
* Healthy adult volunteers
* No present or past psychiatric illness
* No personal history of suicidal behavior and without a family history of suicide
* Provided written informed consent for study participation
* Northern or Western European ancestry (HapMap-CEU)
* Medical insurance coverage
Exclusion Criteria:
Case:
* Inability to get an informed and valid consent
* Home address outside the selected hospitals' geographic areas
* Intellectual disability or organic brain damage
* Origine ethnique non CEU
* Absence of medical insurance coverage
* Pregnant or lactating women
* Without Northern or Western European ancestry (HapMap-CEU)
Control :
* Inability to get an informed and valid consent
* Intellectual disability or organic brain damage
* History of suicidal behavior
* Psychiatric disorder, past or present
* Family history of suicide
* Borderline personality disorder
* Absence of medical insurance coverage
* Pregnant or lactating women
* Without Northern or Western European ances…
What they're measuring
1
Odds ratio (OR) and 95% confidence interval (CI) will be estimated using a logistic regression model to assessing the contribution of each polymorphism as a risk factor in predicting suicidal behavior
Timeframe: Between day 1 and day 5 during hospitalization