Linezolid Instead of Ethambutol in Treatment of Drug-susceptible Tuberculosis

Inclusion Criteria: * Males and females aged from 20 to 80 years (20- and 80-year-old patients can participate). * Documented sputum Xpert MTB/RIF assay-positive pulmonary TB at screening. * On current TB therapy (if any) for ≤14 days at the time of enrollment. Exclusion Criteria: * Patients with HIV/AIDS. * Females of childbearing potential, who are pregnant, breastfeeding, or unwilling to avoid pregnancy. * Any of the following: i.Absolute neutrophil count of \<2000 cells/mL. ii.White blood cell count (WBC) of \<3000/μL. iii.Hemoglobin concentration of \<7.0 g/dL. iv.Serum creatinine level of \>2.0 mg/dL. v.Aspartate aminotransferase (AST or SGOT) of \>100 IU/L. vi.Alanine aminotransferase (ALT or SGPT) of \>100 IU/L. vii.Total bilirubin level of \>2.0 mg/dL. viii.History of optic neuritis or peripheral neuropathy. ix.Other significant laboratory abnormalities (i.e., absolute neutrophil count, creatinine level). x.The need for ongoing therapy with SSRIs, tricyclic antidepressants, serotonin 5-HT1 receptor agonists (triptans), meperidine, buspirone, monoamine oxidase inhibitors (MAOIs), sympathomimetic agents (e.g., pseudoephedrine), vasopressive agents (e.g., epinephrine, norepinephrine), or dopaminergic agents (e.g., dopamine, dobutamine).