After an allergen challenge, the allergic inflammatory response disappears spontaneously. The initiation of the resolution of the inflammatory response is now recognized as a dynamic process, involving active biochemical programs that enable inflamed tissues to return to homeostasis. Recent data established key roles of different specific lipid mediators in the endogenous counter-regulation of inflammation and activation of resolution. Only little is known about kinetics of these specialized pro-resolving lipid mediators during acute allergic inflammation. Therefore, the primary propose of our study is to characterize the temporal evolution of cellular inflammation and specific lipid mediators after allergen challenge.
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Clinical nasal score and measurement of mediators in biological fluids
Timeframe: Measurement of mediators in biological fluids during 72 h after nasal allergen challenge
Clinical nasal score and measurement of mediators in biological fluids.
Timeframe: Measurement and indentification of specific lipid mediators during nasal allergen challenge