CompletedPhase 4

Effect of Intravenous Lidocaine and Dexamethasone Combination on Postoperative Sore Throat, Cough and Hoarseness.

Nepal180 participantsStarted 2013-12

Plain-language summary

Post operative sore throat (POST) following tracheal intubation is a common problem causing dissatisfaction and discomfort to the patients. Prophylactic use of both lidocaine and dexamethasone has been used independently for this purpose. However, there is no study assessing the synergistic analgesic effects of lidocaine and dexamethasone for POST. The purpose of this study is to compare the effect of lidocaine, dexamethasone and lidocaine dexamethasone combination on the incidence and severity of POST.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients of American Society of Anesthesiologist(ASA) physical status 1 \& 2 requiring general anesthesia with endotracheal intubation. * Duration of surgery more than 90 min Exclusion Criteria: * Those with preexisting hoarseness or sorethroat * Smoker * Vocal performer by occupation * Recent or recurrent respiratory tract infection * Risk factors for postoperative aspiration * Obesity * Pregnancy * Receiving analgesics, corticosteroids and calcium channel blockers * Contraindication to corticosteroid medications * Anticipated difficult intubation * Mallampati grade \> 2 * Difficult mask ventilation requiring oral or nasal airway * Cormack and Lehman grade III and IV on laryngoscopy * More than one intubation attempt * Those requiring orogastric or nasogastric tubes

What they're measuring

Assessment of postoperative sore throat at rest and on swallowing.

Timeframe: From 1 to 24 hr following surgery

Trial details

NCT IDNCT01990781

SponsorB.P. Koirala Institute of Health Sciences

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-12