Study of Subcutaneous Injection of Low-dose rhGM-CSF +/- WLL in PAP.

Inclusion Criteria: * Diagnosed PAP patients * Aged 17-80 * Signed informed consent Exclusion Criteria: * Secondary PAP * Received whole lung lavage therapy within 4 weeks before enrollment * Received previous GM-CSF therapy within 6 months before enrollment * WBC≥12,000/ul * fever≥38℃ * Severe edema, severe liver, kidney, lung and cardiovascular disease. * Pregnant，planning to get pregnant or nursing * Inability to express the subjective discomfort * Serious drug allergy history, E.coli preparation or rhGM-CSF serious allergy history