Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma

Inclusion Criteria: * Patients must have tissue confirmation of high grade (WHO Grade IV) glioma including but not limited to glioblastoma, gliosarcoma, glioblastoma with oligodendroglial features, glioblastoma with PNET features. * The patient must have post-operative contrast enhanced imaging (CT or MRI) unless only biopsy performed (in which case post-operative imaging is not routinely obtained. In these patients, the preoperative study will serve as baseline. * Patient should have surgery (biopsy, partial resection or gross total resection) and no additional anti-cancer therapy except the chemoradiation as specified in the protocol. * For those patients in which steroids are clinically indicated, there must be a stable or decreasing dose of steroid medication for ≥ one week prior to the start of infusion. * Patients must be between the ages of 18 and 75 years old. * Patients must have Karnofsky Performance score ≥ 60. * Adequate organ function is needed at time of screening visit including: * ANC ≥ 1500 * Platelets ≥ 100,000 ml * Serum Creatinine ≤ 1.5mg/dl; Cr Clearance should be \>50 mL/min * AST and ALT ≤ 3 times the upper limit of normal * If female of childbearing potential, negative pregnancy test * The patient or his/her legal representative must have the ability to understand and willingness to sign a written informed consent document. * Patient agrees to use an effective method of contraception (hormonal or two barrier methods) while on study and for …