Pilot Study for the SQUEEZE Trial

Inclusion Criteria: Inclusion Criteria for 1 and 3 must be answered YES to be eligible for study. 1\. Age 29 days to less than 18 years of age 2a) Patient has Persistent Signs of Shock including one or more of the following: i) Vasoactive Medication Dependence ii) Hypotension (Systolic Blood Pressure and/or Mean Blood Pressure less than the 5th percentile for age) iii) Abnormal Perfusion (2 or more of: abnormal capillary refill, tachycardia, decreased level of consciousness, decreased urine output) 2b) Suspected or Confirmed Septic Shock (Shock due to Suspected or Confirmed Infectious Cause) 2c) Patient has received initial fluid resuscitation of: Minimum of 40 mL/kg of isotonic crystalloid (0.9% Normal Saline and/or Ringer's Lactate) and/or colloid (5% albumin) as fluid boluses within the previous 6 hours for patients weighing less than 50 kg, OR Minimum of 2 litres (2000 mL) of isotonic crystalloid (0.9% Normal Saline and/or Ringer's Lactate) and/or colloid (5% albumin) as fluid boluses within the previous 6 hours for patients weighing 50 kg or more 3\. Patient has Fluid Refractory Septic Shock as defined by the Presence of all of 2a, 2b, and 2c. Exclusion Criteria: * Patient admitted to the Neonatal Intensive Care Unit (NICU) * Patient requiring resuscitation in the Operating Room (OR) or Post-Anesthetic Care Unit (PACU) * Full active resuscitative treatment not within the goals of care * Shock Secondary to Cause other than Sepsis (i.e. obvious signs of cardiogenic…