SPIROMICS I, SPIROMICS II, and SPIROMICS III are longitudinal observational studies of Chronic Obstructive Pulmonary Disease (COPD) cohort. SPIROMICS I had two primary aims: (1) To find groups of patients with COPD who share certain characteristics; (2) To find new ways of measuring whether or not COPD is getting worse and to provide new ways of testing whether a new treatment is working. SPIROMICS II had three primary aims: (1) To define the natural history of "smokers with symptoms despite preserved spirometry" and characterize the airway mucus abnormalities underlying this condition; (2) To determine the radiographic precursor lesion(s) for emphysema and identify the molecular phenotypes underlying airway disease and emphysema; (3) To advance understanding of the biology of COPD exacerbations through analysis of predisposing baseline phenotypes, exacerbation triggers and host inflammatory response. SPIROMICS III has three primary aims: (1) To identify the main forms of smoking-related airway disease that are caused by pathological airway mucus, their biological underpinnings, and their physiological significance; (2) To identify longitudinal trajectories in established and novel CT measures of emphysema, test how they predict COPD progression, and define their underlying biology; (3) To identify environmental and social determinants of health that impact disease severity and progression and their influence on lung structure, biology, and health disparities in COPD.
Age range
40 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Morbidity
Timeframe: Through study completion, an average of 18 years.
Lung Function
Timeframe: Through study completion, an average of 18 years.
Mortality
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Radiology - Emphysema Volume
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Radiology - Functional Small Airway Disease through Parametric Response Mapping (PRM)
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Radiology - Functional Small Airway Disease through Disease Probability Method (DPM)
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Radiology - Airway Wall Thickness
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Physiology - Lung function (Spirometry)
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Physiology - Lung function (Respiratory Oscillometry)
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Biological - Mucin concentrations
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Biological - MUCQ index
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Biological - Mucin-interacting proteins
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Outdoor concentrations of particulate matter (PM) 2.5
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Outdoor concentrations of nitrogen dioxide (NO2)
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Outdoor concentrations of nitrogen oxides (NOx)
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Outdoor concentrations of ozone (O3)
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Outdoor concentrations of wildfire-derived particulate matter (PM) 2.5
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Indoor concentrations of particulate matter (PM)
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Indoor measurements of temperature
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Indoor measurements of humidity
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Indoor measurements of NO2
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Indoor measurements of air nicotine
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Indoor measurements of settled dust
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Environmental and Social Determinants of Health - Geocoding
Timeframe: Through study completion, an average of 18 years.
SPIROMICS III: Epigenetic
Timeframe: Through study completion, an average of 18 years.