CompletedNot Applicable

Evaluation of a New Approach of the Diagnosis of Constitutional Functional Disorders of Platelets

France322 participantsStarted 2013-02

Plain-language summary

The primary purpose of the study is to evaluate a standardized method of screening for platelet signalling defects in patients with constitutional disorders of platelet function of unknown origin. We hypothesize that such defects are under-diagnosed in patients, due to heavy workup and requirement of relatively large blood sample by conventional biochemical methods. We propose to analyse kinase signalling downstream platelet membrane receptors using multiplex flow cytometry quantification and fluorescent platelet barcoding.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patient consulting for hemorrhagic symptomatology with a bleeding disorder definitely other than of platelet origin (e.g. "low" von Willebrand) / or constitutional platelet disorder (e.g. Glanzmann thrombasthenia) / or with a defect of platelet function of unknown origin, potentially defective in signalling pathway. * Informed consent form * patient with social security insurance or equivalent Exclusion Criteria: * treatment interfering with platelets function within 7 days prior to enrollment * thrombocytopenia \<100G/L * pregnant or lactating females * subjects under juridical protection guardianship or tutelage measure * subjects involved in another clinical trial

What they're measuring

standardise the method between clinical laboratories

Timeframe: 3 years

Trial details

NCT IDNCT01957345

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-06-29

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