X-linked Biological Response to HIV Sensing: the ANRS EP 53 Study (NCT01952587) | Clinical Trial Compass
CompletedNot Applicable
X-linked Biological Response to HIV Sensing: the ANRS EP 53 Study
France90 participantsStarted 2013-11
Plain-language summary
Short title :
X-linked biological response to HIV sensing: the ANRS EP 53 study.
Main outcome :
To demonstrate that HIV-infected women carry the TLR7 c.32A\>T SNP at a higher frequency than uninfected women, arguing in favor of a role of impaired production of IFN-alpha by pDCs in the risk of becoming infected by HIV-1.
Secondary outcome :
To directly demonstrate at a single cell level that the TLR7 c.32A\>T SNP is responsible for a reduce production of IFN-alpha by pDCs after activation of TLR7 by HIV-1 RNA.
Short abstract (public dissemination) :
Male and female display some differences in how their immune system responds to pathogens. This could be related to hormonal or genetic factors located on the X chromosome. This project aims at characterizing X-linked factors that can influence the innate immune response to HIV-1.
Who can participate
Age range18 Years
SexFEMALE
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Inclusion criteria
✓. Caucasian Female
✓. HIV-1 infection (ELISA and western-blot tests)
✓. HIV-infection through the sexual route before 50 years-old
✓. Continuous antiretroviral therapy for more than 6 months
✓. Plasma HIV-1 RNA \<50 copies/ml in the last 6 months
✓. Age \>18-year old
✓. Health insurance
✓. Informed consent
Exclusion criteria
✕. HIV-infection through vertical or parenteral routes
✕. Chronic infectious disease, notably HCV infection (hepatitis C virus)
✕. Acute infectious disease
✕
What they're measuring
1
Frequency (%) of subjects carrying the TRL7 c.32A>T SNP in HIV-infected and healthy women