Efficacy and Tolerability of Hirudoid Cream in Prophylaxis and Treatment Infusion Phlebitis

Inclusion Criteria: * Patients who are admitted to the hospital requiring to receive infusion of a complete nutritional emulsion for 3 days (Kabiven® Peripheral, 1400 kcal, 1920 ml, 750 mosmol/L, pH 5.6), * Aged 18-65 years. * Patients who are able to understand the requirements of the study and agree to sign an informed consent, approved by an Independent Ethic Committee (IEC)/Institutional Review Board (IRB), prior to the study. Exclusion Criteria: * Patients known to be allergic to Hirudoid or any ingredients of Hirudoid * Patients with impaired skin integrity caused by lesion or soft tissue trauma * Patients having skin lesions with ulcerations or any other severe dermatologic disease * Patients has been received a complete nutritional emulsion infusion within 7 days of inclusion * Patients with severe uncontrolled medical conditions, which makes it undesirable or unsafe for the patients to participate in the study, such as: Acute or chronic uncontrolled severe infections,Unstable angina pectoris, symptomatic congestive heart failure, myocardial infarction, serious uncontrolled cardiac arrhythmia or any other clinically serious cardiac disease, Uncontrolled diabetes as defined by fasting serum glucose \> 1.5 x ULN; optimal glycaemic control should be achieved before starting trial therapy, Uncontrolled bleeding * Patients known to have coagulation disorders such as Haemophilia, Thrombocytopenia, Thrombosis, Other severe hematologic conditions like leukaemia, especially…