Early Medication Discontinuation and Long-term Clinical Outcome in FEP

Inclusion Criteria: * A diagnosis of schizophrenia or non-affective psychosis (schizophreniform disorder, schizoaffective disorder, brief psychotic disorder, or psychosis not otherwise specified) (DSM-IV) * Aged 18 to 65 years * Had been treated with antipsychotic drugs for at least 12 months * No history of relapse or exacerbation or had to be asymptomatic (free of positive symptoms of psychosis) at study entry. Exclusion Criteria: * A diagnosis of drug-induced psychosis * Current treatment with clozapine, with mood stabilizing medications (lithium, valproate or carbamazepine) or with depot medication * Had high risk of suicide or violence * Had poor adherence to treatment (missing\>50% of drug, \>50% missed clinic visits, or a history of medication discontinuation)