Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation

Inclusion Criteria: * Age \> 18 years old * Severe secondary mitral regurgitation characterised, according to the European guidelines and recommendations, by a regurgitant volume\>30 mL/beat or an effective regurgitant orifice\>20 mm². * New York heart Association Class≥ II. * Left ventricular ejection fraction between 15% and 40% * Minimum of 1 hospitalization for heart failure within 12 months preceding randomization * Optimal standard of care therapy for heart failure according to investigator. * Not eligible for a mitral surgery intervention according to the Heart Team. * Willingness to participate in the study and signed written informed consent * Affiliation to a health insurance system or a similar system Exclusion Criteria: * Eligible for a mitral surgery intervention according to the Heart Team. * Primary mitral regurgitation. * Myocardial infarction or coronary bypass grafting surgery within three months prior to randomization. * Cardiac resynchronization therapy within three months prior to randomization. * Cardioversion within three months prior to randomization * Transcatheter aortic valve implantation within three months prior to randomization * Need for any cardiovascular surgery (including registration on cardiac transplant list). * Coronary angioplasty within one month prior to randomization. * Previous surgical mitral valve repair. * Renal replacement therapy. * Active infection requiring current antibiotic therapy. * Severe hepatic insufficiency. * Strok…