Stem Cell Fistula Plug in Perianal Crohn's Disease

Inclusion Criteria * Males and females 18-65 years of age. * Residents of the United States. * Crohn's disease with single or multiple draining complex perianal fistulae (definition as below) for at least three months despite standard therapy (definition below). * Concurrent therapies with corticosteroids, 5-ASA drugs, thiopurines, MTX, antibiotics, and anti-TNF therapy are permitted. * All patients should have undergone a colonoscopy in last 12 months to rule out malignant or premalignant condition * Have no contraindications to MR evaluations: e.g. pacemaker or magnetically active metal fragments, claustrophobia * Ability to comply with protocol * Competent and able to provide written informed consent * Must have failed standard medical therapy including anti-TNF agents Exclusion Criteria * Inability to give informed consent. * Clinically significant medical conditions within the six months before administration of MSCs: e.g. myocardial infarction, active angina, congestive heart failure or other conditions that would, in the opinion of the investigators, compromise the safety of the patient. * Specific exclusions: Evidence of hepatitis B, C, or HIV * History of cancer including melanoma (with the exception of localized skin cancers) * Investigational drug within thirty (30) days of baseline * A resident outside the United States * Pregnant or breast feeding. * History of clinically significant auto-immunity (other than Crohn's disease) or any previous example of fat-dir…