UnknownNot Applicable

Muscle Metabolism and Oxygenation During Localized Fatigue-exercise in COPD

Canada20 participantsStarted 2011-09

Plain-language summary

The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and muscle metabolism disturbances.

Who can participate

Age range50 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * COPD (FEV1/FVC \< 0.70 and FEV1 \< 0.80 predicted * Healthy subjects: no evidence of airways obstruction (FEV1/FVC \> 0.70 and FEV1 \> 0.80 predicted) * Smoking history \> 15 pack-years Exclusion Criteria: * Chronic hypoxemia and/or hypercapnia (PaO2 \< 60 mmHg or SpO2 \< 88% at rest and/or PaCO2 \> 45 mmHg) * Recent exacerbation (\< 3 months) * Recent cancer (\< 3 years) * Diabetes * Myopathy, neuromuscular or articular disease * Unstable cardiac disease * Absolute contraindications to exercise testing * Regular physical activity or exercise training program in the last 2 months * Physical activity score \> 9 in the Voorips questionnaire * Thigh skinfold thickness \> 15 mm * BMI \> 30

What they're measuring

Muscle deoxygenation

Timeframe: 45 seconds post-exercise (knee-extension repetitions)

Muscle metabolism

Timeframe: 45 seconds post-exercise (knee extension repetitions)

Trial details

NCT IDNCT01909544

SponsorLaval University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-07

Contact for this trial

Fernanda Ribeiro, PhD candidate

418-656-8711 fernanda.ribeiro@criucpq.ulaval.ca

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