CompletedNot Applicable

Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men

Switzerland30 participantsStarted 2013-08

Plain-language summary

Randomised training intervention. Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell Sarcopenia Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible. Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.

Who can participate

Age range18 Years – 75 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria: -male * no fever at the beginning and during the study * between 60 years and 75 years * non smokers * no known cardiovascular and orthopaedic problems * no cardiac pacemaker * fulfilling the health criteria Exclusion criteria: -female * fever or cold at the beginning or during the study * non MRI compatible metal implants * under 60 years or over 75 years * smoker * cardiovascular or orthopaedic problems * cardiac pacemaker * not fulfilling the health criteria

What they're measuring

Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes

Timeframe: participants will be followed for the duration of training period, an expected average of 7 months

Trial details

NCT IDNCT01905345

SponsorUniversity of Zurich

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-12

View on ClinicalTrials.gov More Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation trials