Oral Treatment for Orthopaedic Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride

Inclusion Criteria: * Male or female patients aged 18 to 80 years. Females participating in the study must be either of non-childbearing potential, or willing to use a highly effective contraceptive method. * Scheduled to undergo standard primary (first-time) one-sided total hip replacement surgery due to primary osteoarthritis. * Patients experiencing pain at rest of at least moderate intensity the day after surgery. Exclusion Criteria: * Patients not suitable for study treatments and rescue medication (RM) or those for whom non-steroidal anti-inflammatory drugs (NSAIDs), opioids, acetyl salicylic acid, pyrazolones or pyrazolidines are contraindicated. * Patients with clinically significant abnormalities in vital signs, safety laboratory tests and 12-lead ECG at screening. * Patients with history of any illness or condition that might pose a risk to the patient or confound the efficacy and safety study results. * Patients using and not suitable to withdraw analgesics other than those specified in the protocol. * Patients using and not suitable for withdrawing any of the prohibited medication specified in the protocol. * Pregnant and breastfeeding women.