Vitamin D Supplementation and the Immune Response

Inclusion Criteria: \- Aged 65 or over subject, * Subjects with a vitamin D levels below 30 ng / ml, * Acceptance of vitamin D (100 000 IU of UVEDOSE ®) * Acceptance of influenza vaccination with INTANZA15 ® * Affiliation to a social security scheme * The subject agrees not to change their eating habits Exclusion Criteria: * Liver disease: cirrhosis, chronic hepatitis. * Renal impairment whatever degree * Hypercalcemia (serum calcium\> 2.6 mol / l) * Hypo-or hyperparathyroidism history, history of renal colic. * Disease / acute infection, moderate or severe (at the discretion of the investigator) on the day of vaccination or febrile illness (temperature ≥ 38 ° C). The subject should not be included in the study as his condition is not cured or her fever has not gone down). * Long-term treatment with bisphosphonates, corticosteroids, anti-inflammatory, anticonvulsant, antiepileptics, fibrates. * Known hypersensitivity to vitamin D * Prior supplementation (in the last year) or supplementation of vitamin D during * Participation at the time of inclusion in the trial, or planned participation during the same period that this trial, another trial on a vaccine, drug, medical device. * Vaccination during the 4 weeks prior to vaccination or immunization of the test set out in the three weeks after vaccination test. * Transfusion of immunoglobulins, blood or blood products during the last 3 months * Congenital or acquired, known or suspected immunodeficiency, immunosuppressive the…