Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome

Inclusion Criteria: * Patients with hemochromatosis, aged \> 30 years, C282Y- homozygote, with serum-ferritin =/\> 1000 µg/L * Patients aged \> 18 years with verified low-risk or intermediate-1 risk of myelodysplastic syndrome, with normal cytogenetics and serum-ferritin \> 1500 µg/L, or with a transfusion history of =/\> red- blood-cell-transfusions. Exclusion Criteria: * Previous or current venesection * MDS patients eligible for hematopoietic stem cell transplantation * Subject complies with one or more of the following standard exclusion criteria for MRI examination; * If the patient has a pacemaker. * If the patient has a neurostimulator * If the patient has a "aneurismeclips" * If the patient has a foreign object in the eye. If yes, what object. * If the patient has a cochlea-/earimplant. * If the patient has a V/P shunt. * If the patient is claustrophobic. * If the patient has an artificial heart valve. * If the patient has known renal failure, eGFR \<30. * If the patient has or will have a liver transplantation. * Other: metal prostheses, metal implant * Presence of inflammation (CRP ≥ 5 mg/L) * Presence of proteinuria or creatinine \> 2 x UNL (Upper Normal Limit) * Estimated glomerular filtration rate (GFR) \< 60 mL/min * ALAT, ASAT, GT or ALP \> 2 x ULN ( Upper Normal Limit) * ALAT \> 90 U/L for women, ALAT \> 140 U/L for men * ASAT \> 70 U/L for women, ASAT \> 90 U/L for men * ALP \> 210 U/L for women and men * GT \> 90 U/L for women ≤ 40 …