Assessment of the Single Dose Pharmacokinetics and Tolerability of Sativex in Patients With Impaired Hepatic Function and Healthy Patients

Inclusion Criteria: * Subject is aged 18 years or above. * Subject is willing and able to give informed consent for participation in the study (see Section 14.2). * Male or female subjects. * All females must have negative pregnancy test results at screening and baseline. * Vital signs (after five minutes resting measured in the supine position) must be within the following ranges: * Body temperature between 35.0-37.5 °C * Systolic blood pressure, 90-150 mmHg * Diastolic blood pressure, 60-90 mmHg * Pulse rate, 40-99 beats per minute (bpm) Blood pressure and pulse will be taken again in a standing position. After two minutes standing, there shall be no more than a 20 mmHg drop in systolic or 10 mmHg drop in diastolic blood pressure, associated with clinical manifestation of postural hypotension. * Subjects must weigh at least 50 kg and have a BMI between 19 and 42 kg/m2 to participate in this study. * Patients with impaired hepatic function must be compliantly on a stable dose of medication and/or treatment regimen (in the opinion of the investigator) for at least 4 weeks prior to the dosing day with no foreseeable plans for change. * Subject is able (in the Investigators opinion) and willing to comply with all study requirements. * Willing and able to communicate well with the Investigator. * Subject is willing for his or her name to be notified to the responsible authorities for participation in this study, as applicable in individual countries. * Subject is willing to all…